Oxidative stress in disease Antioxidant

oxidative stress thought contribute development of wide range of diseases including alzheimer s disease, parkinson s disease, pathologies caused diabetes, rheumatoid arthritis, , neurodegeneration in motor neuron diseases. in many of these cases, unclear if oxidants trigger disease, or if produced secondary consequence of disease , general tissue damage; 1 case in link particularly understood role of oxidative stress in cardiovascular disease. here, low density lipoprotein (ldl) oxidation appears trigger process of atherogenesis, results in atherosclerosis, , cardiovascular disease.

oxidative damage in dna can cause cancer. several antioxidant enzymes such superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione s-transferase etc. protect dna oxidative stress. has been proposed polymorphisms in these enzymes associated dna damage , subsequently individual s risk of cancer susceptibility.

a low calorie diet extends median , maximum lifespan in many animals. effect may involve reduction in oxidative stress. while there evidence support role of oxidative stress in aging in model organisms such drosophila melanogaster , caenorhabditis elegans, evidence in mammals less clear. indeed, 2009 review of experiments in mice concluded manipulations of antioxidant systems had no effect on aging.

diets high in fruit , vegetables, , possibly being rich in antioxidant vitamins, have no established effect on status of health or aging, yet may have more subtle physiological effects, such modifying cell-to-cell communication.