Glutathione Antioxidant

the free radical mechanism of lipid peroxidation.

glutathione cysteine-containing peptide found in forms of aerobic life. not required in diet , instead synthesized in cells constituent amino acids. glutathione has antioxidant properties since thiol group in cysteine moiety reducing agent , can reversibly oxidized , reduced. in cells, glutathione maintained in reduced form enzyme glutathione reductase , in turn reduces other metabolites , enzyme systems, such ascorbate in glutathione-ascorbate cycle, glutathione peroxidases , glutaredoxins, reacting directly oxidants. due high concentration , central role in maintaining cell s redox state, glutathione 1 of important cellular antioxidants. in organisms glutathione replaced other thiols, such mycothiol in actinomycetes, bacillithiol in gram-positive bacteria, or trypanothione in kinetoplastids.