Multivesicular body biogenesis and cargo shuttling ESCRT

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trafficking of membrane bound proteins lysosome using escrt machinery. membrane bound proteins taken cell via endocytosis. ubiquitin tags on protein recognized escrt machinery , recruited endosome. multivesicular bodies formed, fuse lysosome these proteins degraded. adapted from.


multivesicular bodies play large role in transport of ubiquitinated proteins , receptors lysosome. escrt complexes transport ubiquitinated cargo cellular vesicles bud directly cell’s endosomal compartment, forming multivesicular bodies. these multivesicular bodies fuse lysosome causing degradation of cargo. more in-depth description of process, including associated machinery, exists follows:




^ cite error: named reference schmidt invoked never defined (see page).
^ hurley jh, emr sd (2006). escrt complexes: structure , mechanism of membrane-trafficking network . annu rev biophys biomol struct. 35: 277–98. doi:10.1146/annurev.biophys.35.040405.102126. pmc 1648078 . pmid 16689637. 
^ teis d, saksena s, judson bl, emr sd (march 2010). escrt-ii coordinates assembly of escrt-iii filaments cargo sorting , multivesicular body vesicle formation . embo j. 29 (5): 871–83. doi:10.1038/emboj.2009.408. pmc 2837172 . pmid 20134403. 
^ cite error: named reference babst invoked never defined (see page).






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